Psilocybin with psychological support for treatment-resistant depression: six-month follow-up
This open‑label follow‑up of an initial feasibility study found that two doses of psilocybin administered with psychological support produced rapid, large, and sustained reductions in depressive symptoms among patients with treatment‑resistant depression, with effects lasting up to six months. The treatment was generally well tolerated, suggesting psilocybin‑assisted therapy may be a promising new approach for individuals who have not responded to conventional antidepressants.